Baru saja berakhir seri 2009 dengan Rossi sebagai juara dunia, motoGP.com sudah mengeluarkan jadwal untuk balapan MotoGP tahun 2010 secara lengkap. Ada perubahan jadwal dalam urutan perlombaan yang akan digelar, yaitu Republik Ceko yang sedianya diselenggarakan akhir musim dimajukan menjadi tanggal 15 agustus 2010. Berikut jadwal lengkapnya :
| April 11th* | Qatar | Losail |
| April 25th | Japan | Motegi |
| May 2nd | Spain | Jerez |
| May 23rd | France | Le Mans |
| June 6th | Italy | Mugello |
| June 20th | Great Britain | Silverstone |
| June 26th** | Netherlands | Assen |
| July 4th | Catalunya | Catalunya |
| July 18th | Germany | Sachsenring |
| July 25th*** | United States | Laguna Seca |
| August 15th | Czech Republic | Brno |
| August 29th | Indianapolis | Indianapolis |
| September 5th | San Marino & Riviera di Rimini | Misano |
| September 19th | Hungary | Balatonring |
| October 10th | Malaysia | Sepang |
| October 17th | Australia | Phillip Island |
| October 31st | Portugal | Estoril |
| November 7th | Valencia | Ricardo Tormo |
Reserve Circuit: Motorland Aragon Circuit
* Evening race ** Saturday race *** Only MotoGP class
